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Valacyclovir and prednisolone strategy to be... [otol neurotol. 2007] - pubmed - ncbi
AbstractOBJECTIVE:

To investigate the effects of valacyclovir and prednisolone in comparison to that regarding placebo and prednisolone for the treating Bell's palsy, excluding zoster sine herpete.

Prospective, multicenter, randomized placebo-controlled study.

Six academic tertiary referral centers.

Ultimately, 221 patients with Bell's palsy who were treated within seven days of the onset. Serological and polymerase incidents examinations were performed to differentiate Bell's palsy from zoster sine herpete.

The patients were addressed with either valacyclovir (dosage, 1,000 mg/d for five days) plus prednisolone (VP [n = 114]) or placebo plus prednisolone (PP [n = 107]) administered orally.

Recovery on the palsy was looked as a score more than 36 using Yanagihara 40-point scoring system without facial contracture or synkinesis. The patients were accompanied until complete recovery occurred or 6 or more months within the using a poor prognosis.

The overall rate of patient recovery amongst those helped by VP (96. 5%) was significantly better (p < 0 buy acomplia online without prescription. 05) than the rate among those treated with PP (89. 7%). The rate of patient recovery was also analyzed by classifying the initial severity of facial palsy. In cases of complete or severe palsy, the rates of patients treated with VP and PP who recovered were 95. 7% (n = 92) and 86. 6% (n = 82), respectively; the recovery rate for treatment with VP was significantly better than that with PP (p < 0. 05).

The valacyclovir and prednisolone therapy was more effective for Bell's palsy, excluding zoster sine herpete, than the conventional prednisolone therapy. In our knowledge, this can be the first controlled study associated with an antiviral agent inside treatments for an adequate volume of Bell's palsy cases according to an etiologic background.